US 78 highlighted in red | |||||||||||||||||||
Route information | |||||||||||||||||||
Length | 843.3 mi[citation needed] (1,357.2 km) | ||||||||||||||||||
Existed | 1926[citation needed]–present | ||||||||||||||||||
Major junctions | |||||||||||||||||||
West end | ![]() ![]() ![]() | ||||||||||||||||||
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East end | Line Street at Charleston, SC | ||||||||||||||||||
Location | |||||||||||||||||||
Country | United States | ||||||||||||||||||
States | Arkansas, Tennessee, Mississippi, Alabama, Georgia, South Carolina | ||||||||||||||||||
Highway system | |||||||||||||||||||
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U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at US 67 (Future I-57)/Arkansas Highway 226 (AR 226) near Cash, and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus was at US 64/US 70/US 79 (Second Street) in Memphis, Tennessee.