U.S. Route 81 in Oklahoma

U.S. Highway 81
Chisholm Trail Historic Route
US 81 highlighted in red
Route information
Maintained by ODOT
Length	229.28 mi[1] (368.99 km)
Existed	December 7, 1926[2]–present
Major junctions
South end	US 81 south of Terral
Major intersections	US 70 in Waurika US 277 from Ninnekah to Chickasha I-44 / H.E. Bailey Turnpike in Chickasha US 62 in Chickasha I-40 in El Reno US 412 in Enid US 60 / US 64 from Enid to Pond Creek
North end	US-81 south of Caldwell, KS
Location
Country	United States
State	Oklahoma
Counties	Jefferson, Stephens, Grady, Canadian, Kingfisher, Garfield, Grant
Highway system
United States Numbered Highway System List Special Divided Oklahoma State Highway System Interstate US State Turnpikes
← SH-80 → SH-82

U.S. Route 81 (US-81) is a north–south U.S. highway running through the central United States' Great Plains region, from Fort Worth, Texas to the U.S.–Canadian border at Pembina, North Dakota. A 229.28-mile (368.99 km) segment of the highway lies within the state of Oklahoma. US-81 crosses the Red River from Texas south of Terral, passing through several Oklahoma cities, such as Chickasha, El Reno, Kingfisher, and Enid, before entering Kansas north of Renfrow.

The route of US-81 was originally served by the Chisholm Trail, which was used to drive cattle from Texas to Abilene, Kansas. US-81 was established as a primary route of the U.S. highway system at the time of the system's original designation. US-81 was established through Oklahoma on December 7, 1926.