VKORC1

VKORC1
Identifiers
Aliases	VKORC1, EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR, vitamin K epoxide reductase complex subunit 1
External IDs	OMIM: 608547; MGI: 106442; HomoloGene: 11416; GeneCards: VKORC1; OMA:VKORC1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,095,980 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,494,789 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lobe of liver; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; right coronary artery; ; body of pancreas; ; left coronary artery; ; right ovary; ; pituitary gland;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; islet of Langerhans; ; yolk sac; ; urinary bladder; ; liver; ; right kidney; ; proximal tubule; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; vitamin-K-epoxide reductase (warfarin-sensitive) activity; quinone binding; vitamin-K-epoxide reductase (warfarin-insensitive) activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; intracellular membrane-bounded organelle;
Biological process	peptidyl-glutamic acid carboxylation; blood coagulation; bone development; vitamin K metabolic process; response to organonitrogen compound; response to organic cyclic compound; regulation of blood coagulation; response to antibiotic;
	Sources:Amigo / QuickGO
Orthologs
	79001
	27973
	ENSG00000167397
	ENSMUSG00000096145
	Q9BQB6
	Q9CRC0
	NM_001311311; NM_024006; NM_206824
	NM_178600
	NP_001298240; NP_076869; NP_996560
	NP_848715
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene VKORC1 encodes for the enzyme, Vitamin K epOxide Reductase Complex (VKORC) subunit 1.^[5] This enzymatic protein complex is responsible for reducing vitamin K 2,3-epoxide to its active form, which is important for effective clotting (coagulation). In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167397 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000096145 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: VKORC1 vitamin K epoxide reductase complex, subunit 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167397 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000096145 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: VKORC1 vitamin K epoxide reductase complex, subunit 1".

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VKORC1

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