 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (September 2012) |
| Vesiculo_matrix | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of vesicular stomatitis virus matrix protein | |||||||||
| Identifiers | |||||||||
| Symbol | Vesiculo_matrix | ||||||||
| Pfam | PF06326 | ||||||||
| InterPro | IPR009397 | ||||||||
| SCOP2 | 1lg7 / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 381 | ||||||||
| OPM protein | 1lg7 | ||||||||
| |||||||||
The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known as VSIV or VSV. The matrix (M) protein of the virus causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein.[1]
- ^ Kopecky SA, Lyles DS (May 2003). "The cell-rounding activity of the vesicular stomatitis virus matrix protein is due to the induction of cell death". J. Virol. 77 (9): 5524–8. doi:10.1128/jvi.77.9.5524-5528.2003. PMC 153969. PMID 12692256.