Back فيلازودون Arabic Vilazodon German Vilazodona Spanish ویلازودون Persian Vilazodone French ビラゾドン Japanese ଭାଇଲାଜୋଡନ OR Wilazodon Polish Vilazodona Portuguese Vilazodonă Romanian

Vilazodone

Vilazodone
Clinical data
Pronunciation/vɪˈlæzədoʊn/
vi-LAZ-ə-dohn
Trade namesViibryd
Other namesEMD-68843; SB-659746A
AHFS/Drugs.comMonograph
MedlinePlusa611020
License data
Routes of
administration		By mouth
Drug classSerotonin modulator[1]
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability72% (oral, with food)[5]
MetabolismLiver via CYP3A4[5]
Elimination half-life25 hours[5]
ExcretionFaecal and renal[5]
Identifiers
  • 5-(4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H27N5O2
Molar mass441.535 g·mol−1
3D model (JSmol)
  • N#Cc5ccc4[nH]cc(CCCCN3CCN(c2ccc1oc(C(N)=O)cc1c2)CC3)c4c5
  • InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32) checkY
  • Key:SGEGOXDYSFKCPT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder.[1] It is classified as a serotonin modulator[1] and is taken by mouth.[1]

Common side effects include nausea, diarrhea, and trouble sleeping.[1] Serious side effects may include increased suicidal thoughts or actions in those under the age of 25, serotonin syndrome, bleeding, mania, pancreatitis, and SIADH.[1] Vilazodone may cause less emotional blunting than typical SSRIs and SNRIs.[6] A withdrawal syndrome may occur if the dose is rapidly decreased.[1] Use during pregnancy and breastfeeding is not generally recommended.[7] It is in the serotonin modulator class of medications and is believed to work both as an SSRI and activator of the 5-HT1A receptor.[1]

Vilazodone was approved for medical use in the United States in 2011[1] and in Canada in 2018.[8] In 2019, it was the 334th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.[9] The drug lost patent protection in June 2022 for adults and in July 2023 for pediatrics.[10] Generic versions have been approved by the U.S. Food and Drug Administration (FDA).[11][12]

  1. ^ a b c d e f g h i "Vilazodone Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved March 3, 2019.
  2. ^ Anvisa (March 31, 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published April 4, 2023). Archived from the original on August 3, 2023. Retrieved August 16, 2023.
  3. ^ "Viibryd Product information". Health Canada. April 25, 2012. Retrieved June 10, 2022.
  4. ^ "Health Canada New Drug Authorizations: 2015 Highlights". Health Canada. May 4, 2016. Retrieved April 7, 2024.
  5. ^ a b c d e "Viibryd (vilazodone hydrochloride) tablet Viibryd (vilazodone hydrochloride) kit [Forest Laboratories, Inc.]". DailyMed. Forest Laboratories, Inc. December 2012. Archived from the original on October 29, 2013. Retrieved October 28, 2013.
  6. ^ Hughes S, Lacasse J, Fuller RR, Spaulding-Givens J (September 2017). "Adverse effects and treatment satisfaction among online users of four antidepressants". Psychiatry Research. 255: 78–86. doi:10.1016/j.psychres.2017.05.021. PMID 28531820. S2CID 4572360.
  7. ^ "Vilazodone (Viibryd) Use During Pregnancy". Drugs.com. Retrieved March 21, 2019.
  8. ^ "Drug Product Database Online Query". Health Canada. Government of Canada. April 25, 2012. Retrieved May 18, 2020.
  9. ^ "Vilazodone - Drug Usage Statistics". ClinCalc. Archived from the original on July 8, 2020. Retrieved October 16, 2021.
  10. ^ "Generic Viibryd Availability".
  11. ^ "Vilazodone: FDA-Approved Drugs".
  12. ^ "2019 First Generic Drugs Approvals". U.S. Food and Drug Administration (FDA). January 21, 2021. Retrieved June 10, 2022.
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