William Vernon (1719–1806) was a New England trader.
William Vernon may also refer to:
- William H. Vernon (1944–2014), American businessman and politician
- William Tecumseh Vernon (1871–1944), American educator, minister and bishop in the African Methodist Episcopal Church
- William de Vernon, founder of the Vernon family
- William Vernon (died 1467), Knight-Constable of England
- William Warren Vernon (1834–1919), British noble and scholar