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Trade names | Civanex |
Other names | Civamide; (Z)-Capsaicin; cis-Capsaicin |
Routes of administration | Topical |
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ECHA InfoCard | 100.164.527 |
Chemical and physical data | |
Formula | C18H27NO3 |
Molar mass | 305.418 g·mol−1 |
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Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. Zucapsaicin is a member of phenols and a member of methoxybenzenes.[1] It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1 that reduces pain, and improves articular functions.[2][unreliable medical source?][3] It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).[4][5]
Zucapsaicin has been tested for treatment of a variety of conditions associated with ongoing nerve pain. This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis.[6] It was approved by the Health Canada in 2010 as topical cream marketed under the brand name Zuacta but currently not FDA-approved.[2] It has a melting point of 71.5–74.5 °C.[2]