Prolaktina

Prolaktina
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 1RW5, 2Q98, 3D48, 3EW3, 3MZG, 3N06, 3N0P, 3NCB, 3NCC, 3NCE, 3NCF, 3NPZ
Identifikatzaileak
Aliasak	PRL (HUGO), GHA1, prolactin
Kanpoko IDak	OMIM: 176760   MGI: 97762   HomoloGene: 732   GeneCards: PRL   OMA: PRL - orthologs
Genetikoki lotutako gaixotasunak
mammary Paget's disease  [1]
Genearen kokapena (gizakia) Kromosoma: 6 (gizakia)[2] Banda 6p22.3 Hasiera 22.287.244 bp[2] Amaiera 22.302.826 bp[2]
Genearen kokapena (sagua) Kromosoma: 13 (sagua)[3] Banda 13 A3.1|13 12.25 cM Hasiera 27.241.553 bp[3] Amaiera 27.249.188 bp[3]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena hipofisi adenohipofisi Dezidua Gonada Barrabil stromal cell of endometrium  right hemisphere of cerebellum  gastric mucosa  secondary oocyte  body of uterus  Adierazpen ohikoena hipofisi adenohipofisi pars distalis of adenohypophysis  nucleus of stria terminalis  cingulate gyrus  central gray substance of midbrain  Epithelium of choroid plexus  superior frontal gyrus  sensory ganglion  Koklea Erreferentziazko adierazpen datu gehiago BioGPS
Gene ontologia Funtzio molekularra prolactin receptor binding  proteina lotura  hormone activity  Zelularen osagaia zelulaz kanpoko eremu  endosome lumen  secretory granule  extracellular space  Prozesu biologikoa female pregnancy  cell surface receptor signaling pathway  growth hormone receptor signaling pathway via JAK-STAT  lactation  cell population proliferation  positive regulation of receptor signaling pathway via JAK-STAT  regulation of multicellular organism growth  regulation of signaling receptor activity  negative regulation of endothelial cell proliferation  negative regulation of angiogenesis  positive regulation of pri-miRNA transcription by RNA polymerase II  jaiotza  response to nutrient  Erritmo zirkadiano  positive regulation of cell population proliferation  response to organic cyclic compound  regulation of ossification  response to estradiol  response to lipopolysaccharide  cellular response to hormone stimulus  multicellular organismal response to stress  ovulation cycle  response to ethanol  positive regulation of epithelial cell proliferation  mammary gland development  response to nutrient levels  positive regulation of lactation  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 5617 19109 Ensembl ENSG00000172179 ENSMUSG00000021342 UniProt P01236 P06879 RefSeq (RNAm) NM_000948 NM_001163558 NM_001163530 NM_011164 RefSeq (proteina) NP_000939 NP_001157030 NP_001157002 NP_035294 Kokapena (UCSC) Chr 6: 22.29 – 22.3 Mb Chr 13: 27.24 – 27.25 Mb PubMed bilaketa [4] [5]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

Prolaktina (PRL) adenohipofisiko zelula laktotropoek sintetizatu eta jariatzen duten hormona da.

Prohormona bezala sintetizatzen da eta Golgi aparatuan eratutako jariaketa besikuletan pilatzen da. Haurdunaldian bular-guruinek hormona esteroideoen eraginez esnea ekoizteko gaitasuna eskuratzen dute eta prolaktinak prozesua mantendu egiten du.

Egitura kimikoari dagokionez, polipeptido bat da, gizakiarengan 199 aminoazido dituena. Ugariagoa da emakumeengan (batez ere haurdun dauden emakumeengan) gizonezkoengan baino.

1. ↑ Genetikoki lotutako gaixotasunak Prolaktinaikusi/editatu erreferentziak Wikidatan. .
2. ↑ ^{a b c} GRCh38: Ensembl release 89: ENSG00000172179 - Ensembl, May 2017
3. ↑ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000021342 – Ensembl, May 2017
4. ↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.