Back تعطيل مورثة Arabic Нокаут (генетика) Bulgarian Genski nokaut BS Organisme genoanul·lat Catalan Genový knockout Czech Gen-Knockout German Γονιδιακή απενεργοποίηση Greek Gene knockout English Bloqueo de genes Spanish سرکوب ژن Persian
A gene knockout is a genetic technique in which one of an organism's genes is switched off or replaced by one which does not work.
The organisms, such as knockout mice, are used to learn about a gene that has been sequenced, but whose function is unknown or incompletely known. Researchers draw inferences from the difference between the knockout organism and normal individuals. Knockout is often abbreviated as KO.
Gene knock-in is the opposite term. There a gene is switched on, or a working gene inserted.