Secretin

Secretin is a peptide hormone that regulates water balance throughout the body. It is produced in secretory glands of the duodenum.^[1] In humans, the secretin peptide is encoded by the SCT gene, which sits on chromosome 11.^[2]

In 2007, secretin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.^[3][4]

Secretin was the first hormone to be identified.^[5] The crucial experiments were done at University College London in 1902. The term 'hormone' was invented in 1905.^[6]

1. ↑ Häcki WH (1980). "Secretin". Clinics in Gastroenterology. 9 (3): 609–32. doi:10.1016/S0300-5089(21)00474-0. PMID 7000396.
2. ↑ Kopin AS, Wheeler MB, Leiter AB (1990). "Secretin: structure of the precursor and tissue distribution of the mRNA". Proceedings of the National Academy of Sciences of the United States of America. 87 (6): 2299–303. Bibcode:1990PNAS...87.2299K. doi:10.1073/pnas.87.6.2299. JSTOR 2354038. PMC 53674. PMID 2315322.
3. ↑ "Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption". Molecular and Cellular Biology. 27 (7): 2499–511. 2007. doi:10.1128/MCB.01088-06. PMC 1899889. PMID 17283064. {{cite journal}}: Unknown parameter |authors= ignored (help)
4. ↑ "Secretin as a neurohypophysial factor regulating body water homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 106 (37): 15961–6. 2009. Bibcode:2009PNAS..10615961C. doi:10.1073/pnas.0903695106. JSTOR 40484830. PMC 2747226. PMID 19805236. {{cite journal}}: Unknown parameter |authors= ignored (help)
5. ↑ Henriksen JH, Schaffalitzky de Muckadell OB (2002). "Sekretin - det første hormon" [Secretin--the first hormone]. Ugeskrift for Laeger (in Danish). 164 (3): 320–5. PMID 11816326.
6. ↑ Hirst, BH (2004), "Secretin and the exposition of hormonal control", J Physiol, 560 (Pt 2): 339, doi:10.1113/jphysiol.2004.073056, PMC 1665254, PMID 15308687