Back ثلاسيميا ألفا Arabic Α-Thalassämie German Alfa talasemia Spanish Thalassémie alpha French Alfa talassemia Italian Talasemia alfa Malay Alfa-talassemia Portuguese ทาลัสซีเมียแบบแอลฟา Thai
| Alpha-thalassemia | |
|---|---|
| Other names | α-thalassaemia |
 | |
| Alpha-thalassemia inheritance pattern | |
| Specialty | Hematology  |
| Symptoms | Jaundice, Fatigue[1] |
| Causes | Deletions of chromosome 16p.[2] |
| Diagnostic method | Haemoglobin electrophoresis[3] |
| Treatment | Blood transfusion, possible splenectomy[1][4] |
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1[5] and HBA2.[6] Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood.[7] Normal hemoglobin consists of two alpha chains and two beta chains; in alpha-thalassemia, there is a quantitative decrease in the amount of alpha chains, resulting in fewer normal hemoglobin molecules. Furthermore, alpha-thalassemia leads to the production of unstable beta globin molecules which cause increased red blood cell destruction. The degree of impairment is based on which clinical phenotype is present (how many genes are affected).[3]
- ^ a b Cite error: The named reference
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comwas invoked but never defined (see the help page). - ^ Online Mendelian Inheritance in Man (OMIM): Hemoglobin—Alpha locus 1; HBA1 - 141800
- ^ Online Mendelian Inheritance in Man (OMIM): Hemoglobin—Alpha locus 2; HBA2 - 141850
- ^ Lanzkowsky's Manual Of Pediatric Hematology And Oncology 6th Edition ( 2016).