Elastin

Elastin
Identifikatori
Aliasi	ELN
Vanjski ID-jevi	OMIM: 130160 MGI: 95317 GeneCards: ELN
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek)[1] Bend 7q11.23 Početak 74,027,789 bp[1] Kraj 74,069,907 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5 G2|5 74.76 cM Početak 134,731,447 bp[2] Kraj 134,776,177 bp[2]
Ontologija gena Molekularna funkcija • extracellular matrix structural constituent • GO:0001948, GO:0016582 vezivanje za proteine • extracellular matrix constituent conferring elasticity • extracellular matrix binding Ćelijska komponenta • extracellular region • elastic fiber • GO:0005578 Vanćelijski matriks • collagen-containing extracellular matrix Biološki proces • animal organ morphogenesis • Ćelijska proliferacija • extracellular matrix disassembly • extracellular matrix organization • Krvotok • respiratory gaseous exchange by respiratory system • outflow tract morphogenesis • aortic valve morphogenesis • skeletal muscle tissue development • regulation of actin filament polymerization • stress fiber assembly • regulation of smooth muscle cell proliferation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2006	13717
Ensembl	ENSG00000049540	ENSMUSG00000029675
UniProt	P15502	P54320
RefSeq (mRNK)	NM_000501 NM_001081752 NM_001081753 NM_001081754 NM_001081755 NM_001278912 NM_001278913 NM_001278914 NM_001278915 NM_001278916 NM_001278917 NM_001278918 NM_001278939	NM_007925
RefSeq (bjelančevina)	NP_000492 NP_001075221 NP_001075222 NP_001075223 NP_001075224 NP_001265841 NP_001265842 NP_001265843 NP_001265844 NP_001265845 NP_001265846 NP_001265847 NP_001265868	NP_031951
Lokacija (UCSC)	Chr 7: 74.03 – 74.07 Mb	Chr 5: 134.73 – 134.78 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Elastin je komponenta vanćelijskog (ekstracelularnog) matriksa. Struktura mnogih tkiva i organa podrazumijeva istovremenu čvrstinu i elastičnost (krvni sudovi, koža, pluća I druga), što omogućavaju elasinska vlakna. Elastin je redovno uz nerstegljiviji kolagen kako bi se ograničilo rastezanje samog matičnog tkiva. Kod ljudi, elastin je kodiran genom sa lokusa ELN.^[5][6][7][8]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000049540 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000029675 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Curran ME, Atkinson DL, Ewart AK, Morris CA, Leppert MF, Keating MT (1993). "The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis". Cell. 73 (1): 159–68. doi:10.1016/0092-8674(93)90168-P. PMID 8096434. Nepoznati parametar |month= zanemaren (pomoć)CS1 održavanje: više imena: authors list (link)
6. ^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
7. ^ Hadžiselimović R., Pojskić N. (2005): Uvod u humanu imunogenetiku. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-3-4.
8. ^ Međedović S., Maslić E., Hadžiselimović R. (2000): Biologija 2. Svjetlost, Sarajevo, ISBN 9958-10-222-6.