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Clinical data | |
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Pronunciation | /flɛˈkeɪnaɪd/ fleh-KAY-nyde |
Trade names | Tambocor, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608040 |
Drug class | Ic antiarrhythmic[1] |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | 95% |
Protein binding | 40% |
Metabolism | CYP2D6 (limited) |
Elimination half-life | 20 hours (range 12–27 hours) |
Excretion | Kidney |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.211.334 |
Chemical and physical data | |
Formula | C17H20F6N2O3 |
Molar mass | 414.348 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
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Flecainide is a medication used to prevent and treat abnormally fast heart rates.[1] This includes ventricular and supraventricular tachycardias.[1] Its use is only recommended in those with dangerous arrhythmias or when significant symptoms cannot be managed with other treatments.[1] Its use does not decrease a person's risk of death.[1] It is taken by mouth or injection into a vein.[1][3]
Common side effects include dizziness, problems seeing, shortness of breath, chest pain, and tiredness.[1] Serious side effects may include cardiac arrest, arrhythmias, and heart failure.[1] It may be used in pregnancy, but has not been well studied in this population.[3][4] Use is not recommended in those with structural heart disease or ischemic heart disease.[1] Flecainide is a class Ic antiarrhythmic agent.[1] It works by decreasing the entry of sodium in heart cells, causing prolongation of the cardiac action potential.[1]
Flecainide was approved for medical use in the United States in 1985.[1] It is available as a generic medication.[3] In 2021, it was the 205th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[5][6]