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Names | |
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IUPAC name
5-(Aminomethyl)-1,2-oxazol-3(2H)-one
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Other names
Agarin, Pantherine, Agarine, Pantherin
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Identifiers | |
3D model (JSmol)
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774694 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.018.574 |
EC Number |
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KEGG | |
PubChem CID
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UNII | |
UN number | 2811 3077 |
CompTox Dashboard (EPA)
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Properties[1] | |
C4H6N2O2 | |
Molar mass | 114.104 g·mol−1 |
Melting point | 184 to 185 °C (363 to 365 °F; 457 to 458 K) |
very soluble | |
Solubility in ethanol | slightly soluble |
Solubility in methanol | very soluble |
Pharmacology | |
Legal status |
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Hazards | |
GHS labelling:[2] | |
H300 | |
P264, P270, P301+P316, P321, P330, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptor[3] and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. This colorless or white solid is classified as an isoxazole.
Muscimol went under clinical trial phase I for epilepsy, but the trial was discontinued.[4]
Muscimol, an agonist for the GABAA receptor, was able to significantly alleviate pain in its peak effect, recent studies from 2023 show. It has since been federally banned in Australia and is pending FDA review in the United States, but scientists believe it may relieve pain as well as some opioids without much of the risk of addiction associated with opioids. [5]