P53

P53
Estructures disponibles PDB Cerca ortòloga: PDBe RCSB Llista de codis id de PDB 4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA
Àlies	TP53 (HUGO), BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
Identif. externs	OMIM 191170   MGI 98834   HomoloGene: 460   GeneCards: TP53   OMA: TP53 - orthologs
Localització del gen (humà) Crom. Cromosoma 17 (humà)[1] Banda 17p13.1 Inici 7.661.779 bp[1] Fi 7.687.538 bp[1]
Localització del gen (ratolí) Crom. Cromosoma 11 (ratolí)[2] Banda 11 B3|11 42.83 cM Inici 69.471.185 bp[2] Fi 69.482.699 bp[2]
Patró d'expressió d'ARN Bgee humà ratolí (ortòleg) Més explicacions ventricular zone  eminència ganglionar  tendon of biceps brachii  monòcit stromal cell of endometrium  pell de l'abdomen  recte granulòcit skin of leg  múscul llis Més explicacions tail of embryo  genital tubercle  embrió ventricular zone  embrió epiblast  sac vitel·lí llavi blastocist somita Més dades d'expressió de referència BioGPS Més referències a dades d'expressió
Ontologia genètica Funció molecular protein N-terminus binding  DNA-binding transcription factor activity  protein self-association  core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  protein phosphatase binding  unió d'ATP  transcription factor binding  metal ion binding  protein phosphatase 2A binding  enzyme binding  zinc ion binding  chromatin binding  unió de proteasa  damaged DNA binding  unió proteica  histone acetyltransferase binding  copper ion binding  protein kinase binding  chaperone binding  DNA-binding transcription activator activity, RNA polymerase II-specific  receptor tyrosine kinase binding  p53 binding  unió de proteïnes idèntica  protein heterodimerization activity  unió de la proteïna de la ubiquitina  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  TFIID-class transcription factor complex binding  mRNA 3'-UTR binding  histone deacetylase binding  disordered domain specific binding  promoter-specific chromatin binding  histone deacetylase regulator activity  protein homodimerization activity  MDM2/MDM4 family protein binding  Component cel·lular citoplasma  mitocondri  nucli cel·lular  nuclear body  transcription factor TFIID complex  nuclear matrix  replication fork  nuclèol  reticle endoplasmàtic  nucleoplasma  matriu mitocondrial  PML body  citosol  Intracel·lular  transcription regulator complex  complex macromolecular  site of double-strand break  Procés biològic positive regulation of histone deacetylation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  procés rítmic  replicative senescence  negative regulation of telomerase activity  oligodendrocyte apoptotic process  cellular response to DNA damage stimulus  intrinsic apoptotic signaling pathway  positive regulation of neuron apoptotic process  regulation of mitochondrial membrane permeability  positive regulation of reactive oxygen species metabolic process  cellular response to ionizing radiation  positive regulation of thymocyte apoptotic process  negative regulation of helicase activity  cicle cel·lular  Ras protein signal transduction  proliferació cel·lular  cellular response to hypoxia  negative regulation of cell population proliferation  Reparació per excisió de nucleòtid  cellular response to glucose starvation  regulació de la transcripció, modelat amb ADN  response to antibiotic  transcripció, plantilla d'ADN  ER overload response  positive regulation of transcription, DNA-templated  negative regulation of cell growth  via intrínseca de senyalització apoptòtica per mediador de classe p53  positive regulation of peptidyl-tyrosine phosphorylation  procés viral  response to gamma radiation  negative regulation of fibroblast proliferation  positive regulation of intrinsic apoptotic signaling pathway  diferenciació cel·lular  determination of adult lifespan  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  cellular response to UV  DNA damage response, signal transduction by p53 class mediator  negative regulation of apoptotic process  protein tetramerization  oxidative stress-induced premature senescence  positive regulation of release of cytochrome c from mitochondria  circadian behavior  negative regulation of transcription, DNA-templated  protein localization  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  positive regulation of execution phase of apoptosis  desenvolupament d'organisme multicel·lular  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  positive regulation of gene expression  mitotic G1 DNA damage checkpoint signaling  positive regulation of protein oligomerization  positive regulation of apoptotic process  entrainment of circadian clock by photoperiod  response to X-ray  positive regulation of transcription by RNA polymerase II  base-excision repair  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  regulation of cell cycle G2/M phase transition  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of signal transduction by p53 class mediator  apoptosi  transcription by RNA polymerase II  positive regulation of protein export from nucleus  mort cel·lular programada  regulation of apoptotic process  protein deubiquitination  phosphatidylinositol-mediated signaling  negative regulation of transcription by RNA polymerase II  autofàgia  mRNA transcription  cytokine-mediated signaling pathway  positive regulation of RNA polymerase II transcription preinitiation complex assembly  RNA polymerase II preinitiation complex assembly  protein homotetramerization  protein-containing complex assembly  cellular response to gamma radiation  signal transduction by p53 class mediator  cellular response to actinomycin D  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of production of miRNAs involved in gene silencing by miRNA  in utero embryonic development  somitogènesi  release of cytochrome c from mitochondria  hematopoietic progenitor cell differentiation  T cell proliferation involved in immune response  B cell lineage commitment  T cell lineage commitment  response to ischemia  double-strand break repair  regulation of transcription by RNA polymerase II  protein import into nucleus  response to oxidative stress  transforming growth factor beta receptor signaling pathway  gastrulació  negative regulation of neuroblast proliferation  central nervous system development  heart development  ritme circadiari  negative regulation of DNA replication  rRNA transcription  response to UV  response to salt stress  embryo development ending in birth or egg hatching  negative regulation of gene expression  positive regulation of cardiac muscle cell apoptotic process  cerebellum development  negative regulation of transforming growth factor beta receptor signaling pathway  T cell differentiation in thymus  regulation of tissue remodeling  multicellular organism growth  positive regulation of mitochondrial membrane permeability  positive regulation of transcription from RNA polymerase II promoter in response to stress  regulation of cell population proliferation  mitochondrial DNA repair  regulation of DNA damage response, signal transduction by p53 class mediator  regulation of neuron apoptotic process  negative regulation of proteolysis  negative regulation of mitotic cell cycle  bone marrow development  embryonic organ development  protein stabilization  chromosome organization  neuron apoptotic process  regulation of cell cycle  hematopoietic stem cell differentiation  interferon-gamma-mediated signaling pathway  cardiac septum morphogenesis  positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  positive regulation of programmed necrotic cell death  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  regulation of thymocyte apoptotic process  necroptosis  cellular response to UV-C  negative regulation of mitophagy  regulation of mitochondrial membrane permeability involved in apoptotic process  regulation of intrinsic apoptotic signaling pathway by p53 class mediator  negative regulation of production of miRNAs involved in gene silencing by miRNA  negative regulation of glucose catabolic process to lactate via pyruvate  intrinsic apoptotic signaling pathway in response to hypoxia  regulation of fibroblast apoptotic process  negative regulation of reactive oxygen species metabolic process  regulation of cellular senescence  Fonts:Amigo / QuickGO
Ortòlegs Espècies Humà Ratolí Entrez 7157 22059 Ensembl ENSG00000141510 ENSMUSG00000059552 UniProt P04637 P02340 RefSeq (ARNm) NM_001276761 NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 NM_001126118 NM_001276695 NM_001276696 NM_001276697 NM_001276698 NM_001276699 NM_001276760 NM_001127233 NM_011640 RefSeq (proteïna) NP_000537 NP_001119584 NP_001119585 NP_001119586 NP_001119587 NP_001119588 NP_001119589 NP_001119590 NP_001263624 NP_001263625 NP_001263626 NP_001263627 NP_001263628 NP_001263689 NP_001263690 NP_001120705 NP_035770 Localització (UCSC) Chr 17: 7.66 – 7.69 Mb Chr 11: 69.47 – 69.48 Mb Cerca a PubMed [3] [4]
Wikidata
Veure/Editar Humà Veure/Editar Ratolí

La p53 (també coneguda com a proteïna 53 o proteïna tumor 53), és una proteïna supressora tumoral que en humans és codificada pel gen TP53.^[5][6][7][8] És crucial en organismes pluricel·lulars, on regula el cicle cel·lular i d'aquesta manera funciona com a supressora tumoral, i, per tant, està implicada en la prevenció del càncer. Per aquest motiu, la p53 ha estat descrita com a “la guardiana del genoma”, “l'àngel guardiana dels gens”, i “la gran vigilant”, referint-se al seu rol com a conservadora de l'estabilitat prevenint la mutació del genoma.^[9] El nom “p53” fa referència a la seva aparent massa molecular: mitjançant la tècnica de SDS-PAGE s'obté que és una proteïna de 53 quilo Daltons (kDa). Tot i així, si ens basem en càlculs extrets dels residus dels seus aminoàcids, obtenim que la seva massa és en realitat només 43,7 kDa. Aquesta diferència és deguda a la gran quantitat de residus de prolina a la proteïna, que alenteixen la migració de la proteïna a SDS-PAGE, fent que la proteïna sembli més pesada del que realment és.^[10] Aquest efecte s'observa a la p53de moltes espècies, incloent els humans, rosegadors, granotes i peixos.