TSC2

Туберозный склероз 2
Туберозный склероз 2
Идентификаторы
Символ	TSC2 ; LAM; PPP1R160; TSC4
Внешние ID	OMIM: 191092 MGI: 102548 HomoloGene: 462 GeneCards: Ген TSC2
Функция	• GTPase activator activity; • protein binding; • phosphatase binding; • protein homodimerization activity; • protein heterodimerization activity; • 14-3-3 protein binding;
Компонент клетки	• nucleus; • cytoplasm; • Golgi apparatus; • cytosol; • caveola; • membrane; • dendrite; • growth cone; • TSC1-TSC2 complex; • neuronal cell body; • perinuclear region of cytoplasm;
Биологический процесс	• response to hypoxia; • neural tube closure; • negative regulation of protein kinase activity; • protein import into nucleus; • endocytosis; • acute-phase response; • cell cycle arrest; • epidermal growth factor receptor signaling pathway; • heart development; • protein localization; • negative regulation of cell proliferation; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • phosphatidylinositol 3-kinase signaling; • negative regulation of phosphatidylinositol 3-kinase signaling; • vesicle-mediated transport; • cell projection organization; • regulation of endocytosis; • negative regulation of Wnt signaling pathway; • negative regulation of TOR signaling; • positive regulation of Ras GTPase activity; • Fc-epsilon receptor signaling pathway; • negative regulation of MAP kinase activity; • protein kinase B signaling; • innate immune response; • negative regulation of cell size; • regulation of insulin receptor signaling pathway; • negative regulation of insulin receptor signaling pathway; • insulin-like growth factor receptor signaling pathway; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • negative regulation of epithelial cell proliferation; • positive chemotaxis; • protein homooligomerization; • protein heterooligomerization; • regulation of cell cycle; • negative regulation of protein kinase B signaling;
	Источники: Amigo / QuickGO
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Ортологи

Комплекс туберозного склероза 2 (TSC2), также известный как туберин — белок, кодируемый у человека геном TSC2 .

TSC2

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