TSC1

TSC1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 5EJC, 4Z6Y
Identifikatori
Aliasi	TSC1
Vanjski ID-jevi	OMIM: 605284 MGI: 1929183 HomoloGene: 314 GeneCards: TSC1
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek)[1] Bend 9q34.13 Početak 132,891,348 bp[1] Kraj 132,946,874 bp[1]
Lokacija gena (miš) Hrom. Hromosom 2 (miš)[2] Bend 2|2 A3 Početak 28,531,240 bp[2] Kraj 28,581,179 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • chaperone binding • GO:0001948, GO:0016582 vezivanje za proteine • protein N-terminus binding • Hsp70 protein binding • ATPase inhibitor activity • Hsp90 protein binding • GTPase activating protein binding Ćelijska komponenta • citoplazma • cell cortex • growth cone • intracellular membrane-bounded organelle • lamellipodium • membrana • Mikronit • TSC1-TSC2 complex • citoskelet • citosol • jedro • perinuklearno područje citoplazme • Lipidna kapljica • ćelijska membrana • projekcija ćelije • GO:0009327 makromolekulani kompleks • chaperone complex • GO:0097483, GO:0097481 postsynaptic density Biološki proces • rRNA export from nucleus • regulation of cell cycle • neural tube closure • cerebral cortex development • memory T cell differentiation • regulation of protein kinase activity • positive regulation of focal adhesion assembly • myelination • GO:1903105 negative regulation of insulin receptor signaling pathway • synapse organization • regulation of translation • hippocampus development • regulation of phosphoprotein phosphatase activity • cell-matrix adhesion • potassium ion transport • adaptive immune response • protein heterooligomerization • Nefrogeneza • nervous system development • cell projection organization • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • regulation of focal adhesion assembly • glucose import • regulation of cell-matrix adhesion • negative regulation of cell size • response to insulin • cardiac muscle cell differentiation • negative regulation of translation • negative regulation of cell population proliferation • cellular response to oxygen-glucose deprivation • adult locomotory behavior • negative regulation of TOR signaling • regulation of neuron death • negative regulation of macroautophagy • negative regulation of neuron projection development • positive regulation of macroautophagy • GO:0034259 negative regulation of GTPase activity • regulation of stress fiber assembly • positive regulation of stress fiber assembly • negative regulation of oxidative stress-induced neuron death • negative regulation of ATP-dependent activity • protein stabilization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7248	64930
Ensembl	ENSG00000165699	ENSMUSG00000026812
UniProt	Q92574	Q9EP53
RefSeq (mRNK)	NM_000368 NM_001008567 NM_001162426 NM_001162427 NM_001362177	NM_022887 NM_001289575 NM_001289576
RefSeq (bjelančevina)	NP_000359 NP_001155898 NP_001155899 NP_001349106	NP_001276504 NP_001276505 NP_075025
Lokacija (UCSC)	Chr 9: 132.89 – 132.95 Mb	Chr 2: 28.53 – 28.58 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein 1 gomoljaste skleroze (TSC1), poznat i kao hamartin, je protein koji je kod ljudi kodiran genom TSC1.^[5]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000165699 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000026812 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: TSC1 tuberous sclerosis 1".