Epidermal growth factor

EGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IVO, 1JL9, 1NQL, 1P9J, 2KV4, 3NJP
Identifiers
Aliases	EGF, HOMG4, URG, epidermal growth factor, epithelial growth factor
External IDs	OMIM: 131530; MGI: 95290; HomoloGene: 1483; GeneCards: EGF; OMA:EGF - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 109,912,883 bp[1] End 110,013,766 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 58.5 cM Start 129,471,214 bp[2] End 129,548,965 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla body of pancreas muscle of thigh human kidney kidney tubule gastrocnemius muscle Skeletal muscle tissue of rectus abdominis biceps brachii deltoid muscle vastus lateralis muscle Top expressed in submandibular gland human kidney right kidney parotid gland vestibular membrane of cochlear duct prostate lobe of prostate extensor digitorum longus muscle plantaris muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transmembrane receptor protein tyrosine kinase activator activity epidermal growth factor receptor binding Wnt-protein binding protein binding growth factor activity Wnt-activated receptor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component integral component of membrane membrane receptor complex extracellular region lysosomal membrane extracellular exosome platelet alpha granule lumen extracellular space clathrin-coated vesicle membrane plasma membrane Biological process negative regulation of epidermal growth factor receptor signaling pathway positive regulation of MAP kinase activity epidermal growth factor receptor signaling pathway regulation of protein localization to cell surface ERK1 and ERK2 cascade platelet degranulation regulation of calcium ion import mammary gland alveolus development MAPK cascade DNA replication positive regulation of transcription, DNA-templated negative regulation of secretion positive regulation of hyaluronan biosynthetic process positive regulation of peptidyl-threonine phosphorylation positive regulation of ubiquitin-dependent protein catabolic process angiogenesis Wnt signaling pathway involved in dorsal/ventral axis specification positive regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of cerebellar granule cell precursor proliferation canonical Wnt signaling pathway negative regulation of cholesterol efflux peptidyl-tyrosine phosphorylation positive regulation of DNA binding positive regulation of phosphorylation positive regulation of mitotic nuclear division branching morphogenesis of an epithelial tube signal transduction regulation of peptidyl-tyrosine phosphorylation ERBB2 signaling pathway phosphatidylinositol phosphate biosynthetic process positive regulation of protein tyrosine kinase activity activation of transmembrane receptor protein tyrosine kinase activity regulation of cell motility positive regulation of receptor internalization positive regulation of epidermal growth factor-activated receptor activity membrane organization negative regulation of ERBB signaling pathway embryonic retina morphogenesis in camera-type eye positive regulation of gene expression positive regulation of cell migration positive regulation of protein kinase B signaling negative regulation of Notch signaling pathway regulation of receptor signaling pathway via JAK-STAT positive regulation of canonical Wnt signaling pathway positive regulation of protein localization to early endosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1950 13645 Ensembl ENSG00000138798 ENSMUSG00000028017 UniProt P01133 P01132 RefSeq (mRNA) NM_001178130 NM_001178131 NM_001963 NM_001357021 NM_010113 NM_001310737 NM_001329594 RefSeq (protein) NP_001171601 NP_001171602 NP_001954 NP_001343950 NP_001297666 NP_001316523 NP_034243 Location (UCSC) Chr 4: 109.91 – 110.01 Mb Chr 3: 129.47 – 129.55 Mb PubMed search [3] [4]
Wikidata
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Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa^[5] and has 53 amino acid residues and three intramolecular disulfide bonds.^[6]

EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine. EGF has since been found in many human tissues, including platelets,^[7] submandibular gland (submaxillary gland),^[8] and parotid gland.^[8] Initially, human EGF was known as urogastrone.^[9]