HDAC1

HDAC1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4BKX, 5ICN
Identifikatori
Aliasi	HDAC1
Vanjski ID-jevi	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p35.2-p35.1 Početak 32,292,083 bp[1] Kraj 32,333,635 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 D2.2|4 63.26 cM Početak 129,409,897 bp[2] Kraj 129,436,506 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • GO:0001106 transcription corepressor activity • histone deacetylase activity • protein N-terminus binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • protein deacetylase activity • histone deacetylase binding • GO:0000975 transcription cis-regulatory region binding • NF-kappaB binding • deacetylase activity • GO:0001948, GO:0016582 vezivanje za proteine • nucleosomal DNA binding • vezivanje enzima • hydrolase activity • core promoter sequence-specific DNA binding • p53 binding • transcription factor binding • RNA polymerase II core promoter sequence-specific DNA binding • vezivanje sa DNK • chromatin binding • Krueppel-associated box domain binding • E-box binding • promoter-specific chromatin binding Ćelijska komponenta • citoplazma • NuRD complex • citosol • histone deacetylase complex • Sin3 complex • nukleoplazma • jedro • Hromatin • GO:0035328 heterochromatin • transcription regulator complex • transcription repressor complex • GO:0009327 makromolekulani kompleks • neuronal cell body • Sin3-type complex Biološki proces • hair follicle placode formation • epidermal cell differentiation • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • rhythmic process • negative regulation of androgen receptor signaling pathway • embryonic digit morphogenesis • negative regulation of apoptotic process • Koagulacija (krv) • GO:1901227 negative regulation of transcription by RNA polymerase II • eyelid development in camera-type eye • circadian regulation of gene expression • negative regulation of gene expression • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • odontogenesis of dentin-containing tooth • protein deacetylation • histone H4 deacetylation • fungiform papilla formation • negative regulation of myotube differentiation • GO:0022415 viral process • histone deacetylation • negative regulation of canonical Wnt signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • regulation of signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • beta-catenin-TCF complex assembly • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • histone H3 deacetylation • regulation of megakaryocyte differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • endoderm development • Jednodnevni biološki ritam • hippocampus development • neuron differentiation • negative regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of oligodendrocyte differentiation • regulation of endopeptidase activity • regulation of amyloid-beta clearance • negative regulation of intrinsic apoptotic signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3065	433759
Ensembl	ENSG00000116478	ENSMUSG00000028800
UniProt	Q13547	O09106
RefSeq (mRNK)	NM_004964	NM_008228
RefSeq (bjelančevina)	NP_004955	NP_032254
Lokacija (UCSC)	Chr 1: 32.29 – 32.33 Mb	Chr 4: 129.41 – 129.44 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Histon-deacetilaza 1 (HDAC1) jest enzim koji je kod ljudi kodiran genom HDAC1 sa hromosoma 1.^[5]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000028800 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Taunton J, Hassig CA, Schreiber SL (april 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. Bibcode:1996Sci...272..408T. doi:10.1126/science.272.5260.408. PMID 8602529. S2CID 25717734.