HDAC1

HDAC1
Estructures disponibles
PDB	Cerca ortòloga: PDBe RCSB
Llista de codis id de PDB
	4BKX, 5ICN
Identificadors
Àlies	HDAC1 (HUGO), GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
IDs externes	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1 OMA: HDAC1 - orthologs
Localització del gen (humà)
Crom.	Cromosoma 1 (humà)
Fi	32.333.635 bp
Localització del gen (ratolí)
Crom.	Cromosoma 4 (ratolí)
Fi	129.436.506 bp
Patró d'expressió d'ARN
	Més explicacions
	mucosa of colon ; ; mucosa of sigmoid colon ; ; mucosa of transverse colon ; ; epithelium of nasopharynx ; ; recte; ; gangli limfàtic; ; pílor; ; right uterine tube ; ; cec; ; geniva;
	Més explicacions
	tail of embryo ; ; genital tubercle ; ; mòrula; ; ventricular zone ; ; medul·la òssia; ; sac vitel·lí; ; tim; ; embrió; ; blastocist; ; placenta;
	Més dades d'expressió de referència
	Més referències a dades d'expressió
Ontologia genètica
Funció molecular	RNA polymerase II cis-regulatory region sequence-specific DNA binding ; NAD-dependent histone deacetylase activity (H3-K14 specific) ; transcription corepressor activity ; histone deacetylase activity ; protein N-terminus binding ; DNA-binding transcription factor activity ; protein deacetylase activity ; histone deacetylase binding ; transcription cis-regulatory region binding ; NF-kappaB binding ; deacetylase activity ; unió proteica ; nucleosomal DNA binding ; enzyme binding ; activitat hidrolasa ; core promoter sequence-specific DNA binding ; p53 binding ; transcription factor binding ; RNA polymerase II core promoter sequence-specific DNA binding ; DNA binding ; chromatin binding ; Krueppel-associated box domain binding ; E-box binding ; promoter-specific chromatin binding ;
Component cel·lular	citoplasma ; NuRD complex ; citosol ; histone deacetylase complex ; Sin3 complex ; nucleoplasma ; nucli cel·lular ; cromatina ; Heterocromatina ; transcription regulator complex ; transcription repressor complex ; complex macromolecular ; cos cel·lular neuronal ; Sin3-type complex ;
Procés biològic	hair follicle placode formation ; epidermal cell differentiation ; chromatin remodeling ; regulació de la transcripció, modelat amb ADN ; procés rítmic ; negative regulation of androgen receptor signaling pathway ; embryonic digit morphogenesis ; negative regulation of apoptotic process ; coagulació de la sang ; negative regulation of transcription by RNA polymerase II ; eyelid development in camera-type eye ; circadian regulation of gene expression ; negative regulation of gene expression ; positive regulation of transcription, DNA-templated ; odontogenesis of dentin-containing tooth ; protein deacetylation ; histone H4 deacetylation ; fungiform papilla formation ; negative regulation of myotube differentiation ; procés viral ; histone deacetylation ; negative regulation of canonical Wnt signaling pathway ; positive regulation of transcription by RNA polymerase II ; transcripció, plantilla d'ADN ; regulation of signal transduction by p53 class mediator ; DNA methylation-dependent heterochromatin assembly ; beta-catenin-TCF complex assembly ; chromatin organization ; positive regulation of cell population proliferation ; negative regulation of transcription, DNA-templated ; histone H3 deacetylation ; regulation of megakaryocyte differentiation ; regulation of transcription by RNA polymerase II ; endoderm development ; ritme circadiari ; hippocampus development ; neuron differentiation ; negative regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of oligodendrocyte differentiation ; regulation of endopeptidase activity ; regulation of amyloid-beta clearance ; negative regulation of intrinsic apoptotic signaling pathway ;
	Fonts:Amigo / QuickGO
Ortòlegs
	3065
	433759
	ENSG00000116478
	ENSMUSG00000028800
	Q13547
	O09106
	NM_004964
	NM_008228
	NP_004955
	NP_032254
	Wikidata
Veure/Editar Humà	Veure/Editar Ratolí

La histona deacetilasa 1 (HDAC1) és un enzim codificat en humans pel gen HDAC1.^[5]

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017
↑ «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Taunton J, Hassig CA, Schreiber SL «A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p». Science, 272, 5260, May 1996, pàg. 408–11. PMID: 8602529.

[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017

[3] «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8602529-5] Taunton J, Hassig CA, Schreiber SL «A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p». Science, 272, 5260, May 1996, pàg. 408–11. PMID: 8602529.

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HDAC1

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